Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women’s Health Initiative
Identifieur interne : 002D05 ( Main/Exploration ); précédent : 002D04; suivant : 002D06Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women’s Health Initiative
Auteurs : Yang Zhou [États-Unis] ; Rowan Chlebowski [États-Unis] ; Michael J. Lamonte [États-Unis] ; Jennifer W. Bea [États-Unis] ; Lihong Qi [États-Unis] ; Robert Wallace [États-Unis] ; Sayeh Lavasani [États-Unis] ; Brian W. Walsh [États-Unis] ; Garnet Anderson [États-Unis] ; Mara Vitolins [États-Unis] ; Gloria Sarto [États-Unis] ; Melinda L. Irwin [États-Unis]Source :
- Gynecologic oncology [ 0090-8258 ] ; 2014.
Abstract
Ovarian cancer is often diagnosed at late stages and consequently the 5-year survival rate is only 44%. However, there is limited knowledge of the association of modifiable lifestyle factors, such as physical activity and obesity on mortality among women diagnosed with ovarian cancer. The purpose of our study was to prospectively investigate the association of (1) measured body mass index (BMI), and (2) self-reported physical activity with ovarian cancer-specific and all-cause mortality in postmenopausal women enrolled in the Women’s Health Initiative (WHI).
Participants were 600 women diagnosed with primary ovarian cancer subsequent to enrollment in WHI. Exposure data, including measured height and weight and reported physical activity from recreation and walking, used in this analysis were ascertained at the baseline visit for the WHI. Cox proportional hazard regression was used to examine the associations between BMI, physical activity and mortality endpoints.
Vigorous-intensity physical activity was associated with a 26% lower risk of ovarian cancer specific-mortality (HR=0.74; 95% CI: 0.56–0.98) and a 24% lower risk of all-cause mortality (HR=0.76; 95% CI: 0.58–0.98) compared to no vigorous-intensity physical activity. BMI was not associated with mortality.
Participating in vigorous-intensity physical activity, assessed prior to ovarian cancer diagnosis, appears to be associated with a lower risk of ovarian cancer mortality.
Url:
DOI: 10.1016/j.ygyno.2014.01.033
PubMed: 24680584
PubMed Central: 4064800
Affiliations:
- États-Unis
- Arizona, Californie, Caroline du Nord, Connecticut, Iowa, Massachusetts, Michigan, Washington (État), Wisconsin, État de New York
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Irwin</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24680584</idno><idno type="pmc">4064800</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064800</idno><idno type="RBID">PMC:4064800</idno><idno type="doi">10.1016/j.ygyno.2014.01.033</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003311</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003311</idno><idno type="wicri:Area/Pmc/Curation">003310</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003310</idno><idno type="wicri:Area/Pmc/Checkpoint">001D17</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001D17</idno><idno type="wicri:Area/Ncbi/Merge">006494</idno><idno type="wicri:Area/Ncbi/Curation">006494</idno><idno type="wicri:Area/Ncbi/Checkpoint">006494</idno><idno type="wicri:doubleKey">0090-8258:2014:Zhou Y:body:mass:index</idno><idno type="wicri:Area/Main/Merge">002D10</idno><idno type="wicri:Area/Main/Curation">002D05</idno><idno type="wicri:Area/Main/Exploration">002D05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women’s Health Initiative</title><author><name sortKey="Zhou, Yang" sort="Zhou, Yang" uniqKey="Zhou Y" first="Yang" last="Zhou">Yang Zhou</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Chlebowski, Rowan" sort="Chlebowski, Rowan" uniqKey="Chlebowski R" first="Rowan" last="Chlebowski">Rowan Chlebowski</name><affiliation wicri:level="2"><nlm:aff id="A2">David Geffen School of Medicine, University of California, Los Angeles, Torrance, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>David Geffen School of Medicine, University of California, Los Angeles, Torrance</wicri:cityArea></affiliation></author><author><name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J." last="Lamonte">Michael J. Lamonte</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Bea, Jennifer W" sort="Bea, Jennifer W" uniqKey="Bea J" first="Jennifer W." last="Bea">Jennifer W. Bea</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Arizona Cancer Center, Tucson, AZ</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>University of Arizona Cancer Center, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Biostatistics, School of Medicine, University of California, Davis, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Biostatistics, School of Medicine, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Wallace, Robert" sort="Wallace, Robert" uniqKey="Wallace R" first="Robert" last="Wallace">Robert Wallace</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Lavasani, Sayeh" sort="Lavasani, Sayeh" uniqKey="Lavasani S" first="Sayeh" last="Lavasani">Sayeh Lavasani</name><affiliation wicri:level="2"><nlm:aff id="A7">Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Walsh, Brian W" sort="Walsh, Brian W" uniqKey="Walsh B" first="Brian W." last="Walsh">Brian W. Walsh</name><affiliation wicri:level="2"><nlm:aff id="A8">Center for Reproductive Medicine, Brigham and Women’s Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Reproductive Medicine, Brigham and Women’s Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Garnet" sort="Anderson, Garnet" uniqKey="Anderson G" first="Garnet" last="Anderson">Garnet Anderson</name><affiliation wicri:level="2"><nlm:aff id="A9">School of Public Health, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>School of Public Health, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Vitolins, Mara" sort="Vitolins, Mara" uniqKey="Vitolins M" first="Mara" last="Vitolins">Mara Vitolins</name><affiliation wicri:level="2"><nlm:aff id="A10">Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Sarto, Gloria" sort="Sarto, Gloria" uniqKey="Sarto G" first="Gloria" last="Sarto">Gloria Sarto</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Irwin, Melinda L" sort="Irwin, Melinda L" uniqKey="Irwin M" first="Melinda L." last="Irwin">Melinda L. Irwin</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Division of Chronic Disease Epidemiology, Yale School of Public Health, New Haven</wicri:cityArea></affiliation></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="ISSN">0090-8258</idno><idno type="eISSN">1095-6859</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Ovarian cancer is often diagnosed at late stages and consequently the 5-year survival rate is only 44%. However, there is limited knowledge of the association of modifiable lifestyle factors, such as physical activity and obesity on mortality among women diagnosed with ovarian cancer. The purpose of our study was to prospectively investigate the association of (1) measured body mass index (BMI), and (2) self-reported physical activity with ovarian cancer-specific and all-cause mortality in postmenopausal women enrolled in the Women’s Health Initiative (WHI).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Participants were 600 women diagnosed with primary ovarian cancer subsequent to enrollment in WHI. Exposure data, including measured height and weight and reported physical activity from recreation and walking, used in this analysis were ascertained at the baseline visit for the WHI. Cox proportional hazard regression was used to examine the associations between BMI, physical activity and mortality endpoints.</p></sec><sec id="S3"><title>Results</title><p id="P3">Vigorous-intensity physical activity was associated with a 26% lower risk of ovarian cancer specific-mortality (HR=0.74; 95% CI: 0.56–0.98) and a 24% lower risk of all-cause mortality (HR=0.76; 95% CI: 0.58–0.98) compared to no vigorous-intensity physical activity. BMI was not associated with mortality.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Participating in vigorous-intensity physical activity, assessed prior to ovarian cancer diagnosis, appears to be associated with a lower risk of ovarian cancer mortality.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li><li>Californie</li><li>Caroline du Nord</li><li>Connecticut</li><li>Iowa</li><li>Massachusetts</li><li>Michigan</li><li>Washington (État)</li><li>Wisconsin</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Zhou, Yang" sort="Zhou, Yang" uniqKey="Zhou Y" first="Yang" last="Zhou">Yang Zhou</name></region><name sortKey="Anderson, Garnet" sort="Anderson, Garnet" uniqKey="Anderson G" first="Garnet" last="Anderson">Garnet Anderson</name><name sortKey="Bea, Jennifer W" sort="Bea, Jennifer W" uniqKey="Bea J" first="Jennifer W." last="Bea">Jennifer W. Bea</name><name sortKey="Chlebowski, Rowan" sort="Chlebowski, Rowan" uniqKey="Chlebowski R" first="Rowan" last="Chlebowski">Rowan Chlebowski</name><name sortKey="Irwin, Melinda L" sort="Irwin, Melinda L" uniqKey="Irwin M" first="Melinda L." last="Irwin">Melinda L. Irwin</name><name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J." last="Lamonte">Michael J. Lamonte</name><name sortKey="Lavasani, Sayeh" sort="Lavasani, Sayeh" uniqKey="Lavasani S" first="Sayeh" last="Lavasani">Sayeh Lavasani</name><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><name sortKey="Sarto, Gloria" sort="Sarto, Gloria" uniqKey="Sarto G" first="Gloria" last="Sarto">Gloria Sarto</name><name sortKey="Vitolins, Mara" sort="Vitolins, Mara" uniqKey="Vitolins M" first="Mara" last="Vitolins">Mara Vitolins</name><name sortKey="Wallace, Robert" sort="Wallace, Robert" uniqKey="Wallace R" first="Robert" last="Wallace">Robert Wallace</name><name sortKey="Walsh, Brian W" sort="Walsh, Brian W" uniqKey="Walsh B" first="Brian W." last="Walsh">Brian W. Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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